Taizo Taniguchi, Mariko Takenokuchi, Kazuhide Miyamoto, Keiichi Kadoyama, Hiromi
Takano-Ohmuro, Hirotsugu Yamaguchi
Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Himeji, Japan
Background: Murasaki, Lithospermum erythrorhizon has been grown in Japan since ancient times. The root of murasaki which is called "shikon" in Japan has been used as a natural medicine. The active component of shikon is Shikonin. Although Shikonin has many pharmacological effects, it is very difficult to extract from shikon. Shikonin is also very unstable under oxidative conditions or UV radiation. In this study, we show our recent works on Shikonin.
1. We developed a very effective way to extract and purify Shikonin from shikon.
2. We succeeded to make a stable and soluble shikonin by wrapped with beta-glucan (Product name "WAKI○R")
3. WAKI shows unique effects, some of which are not observed in Shikonin. Shikonin promotes wound healing, shows anti-inflammatory effects, and WAKI promotes growth of hair and Eyelashes.
These results indicate that Shikonin is a good seed compound for drug development and WAKI a new promising cosmetic raw material.
Keywords: Shikonin, cosmetic material.