Mona Ismail Gomaa, Asmaa Owis, Rabab Mohammed, Abeer A.A. Salama and Mona Hettaa
Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt;
Asthma is a chronic disease characterized by inflammation of the airways associated with a hyperresponsiveness of the immune system. According to WHO about 300 million people worldwide suffered from asthma.
Euphorbiaceae, the spurge family, is one of the largest families of flowering plants with 300 genera and around 7,500 species. The plants produce large number of diverse secondary metabolites such as terpenoids, tannins, polyphenols and flavonoids. Various species of the genus Euphorbia are used for the treatment of cancer, diarrhea and bronchial asthma.
The aim of this work is testing the activity of Euphorbia grandialata as anti-asthmatic natural agents.
The total alcohol extract of Euphorbia grandialata was tested in vivo after induction of asthma in rats. Lung content of TNF-α, Ig-E, MDA and GSH was determined in blood samples of all rats after 24 hrs. Assessment of early airway reaction was performed 12 min. after the last challenge as Tidal volume (TV) and Peak expiratory flow (PEF).
Results showed that Euphorbia grandialata significantly decreased TNF-α, Ig-E & MDA and significantly increased GSH, TV & PEF as compared with OVA (Challenge) group.
It could be concluded that Euphorbia grandialata could be of great merit as natural anti-asthmatic agent.
Euphorbiaceae, asthma, flavonoids.