T. Sireesha, S. Asha, G. Shravan Kumar, M. Uma Devi and J. Malathi
SSCP, Warangal, Hyderabad, India
Mycobacterium tuberculosis is very important pathogen leads to the prevalence of drug resistance such as MDR & XDR. A cell wall protein HsaD is essential for survival inside the host macrophages. Protein is a meta-cleavage product (MCP) hydrolase that catalyzes the hydrolytic cleavage of a carbon–carbon bond in cholesterol metabolism. The three-dimensional structure of the protein from M. tuberculosis has been determined by X-ray crystallography. Hence, insilico protein structure prediction methods are step into generate a protein structure. Molecular modeling of proteins is a rapidly growing. The present study deals with homology modeling of isolated HsaD protein of M. tuberculosis by using Modeler 9.15. The model shows that 86.8% of amino acids in most favored region. HsaD is critical for Cholesterol metabolism which represents a novel target for antituberculosis therapy.
Keywords: HsaD, MCP, Mycobacterium tuberculosis.